Brief Score
94/100
Updated August 2026
CoreAge Rx
The steadiest desk in the ranking: one flat, no-step-up price on both molecules, nationwide, and it hasn't moved.
- Sema
- $99/mo
- Tirz
- $149/mo
- Coverage
- All 50 states
Alternatives to Synergy Rx
Synergy Rx sits at No. 145 in our ranking with a Brief Score of 67. Here are the GLP-1 desks we'd weigh against it — ranked on the same six-factor Brief Score, top down.
Prefer a straight head-to-head? CoreAge Rx vs Synergy Rx.
Our top alternative
More desks worth weighing
No. 38 · Grade C
79/100Luvo Health
A longevity-leaning telehealth brand ("Longevity-focused care for real life") that publishes a full 4/12/24/52-week term ladder for compounded semaglutide and tirzepatide, plus a real brand-name Ozempic route and a separate NAD+/Sermorelin longevity line — all static pricing, no quiz.
- Sema
- $249/4-wk injection or $279/4-wk tablets — as low as $45/wk (injection), but only on a prepaid 52-wk term
- Coverage
- Not disclosed
No. 85 · Grade C
72/100RxSpan MD
One of the few desks in this ranking that names its pharmacies, its prescribers and their NPI numbers, and publishes every rung of both ladders — while its own API carries cheaper GLP-1 prices that no page will sell you.
- Sema
- $249/mo month-to-month, compounded — the funnel pre-selects a 3-month prepay at $657 up front, and its cheapest rung is $2,327 for a year in one charge
- Coverage
- All 50 states claimed — asynchronous review is not available in all of them
No. 158 · Grade C
69/100NuDay Rx
NuDay Rx is a GLP-1 weight-loss telehealth service (on the CareValidate/careGLP platform) that pairs medication with video coaching and lifestyle support.
- Sema
- From $249/mo (compounded)
- Coverage
- Coverage not published
No. 125 · Grade C
71/100Layla
Layla is a US telehealth weight-loss program built around semaglutide, offering compounded semaglutide as injections and as oral dropper drops, plus compounded tirzepatide and a brand-inclusive GLP-1…
- Sema
- From $237/mo (all doses, compounded)
- Coverage
- Coverage not published
No. 400 · Grade C
56/100Open Water Rx
Open Water Rx is a telehealth platform positioned around GLP-1 weight loss and longevity, per its own site.
- Sema
- From $249/mo (compounded)
- Coverage
- Coverage not published
No. 163 · Grade C
68/100CLYR Health
CLYR Health is a Florida-based telehealth pharmacy offering compounded GLP-1 weight-loss injections alongside sexual-health, longevity and wellness treatments.
- Sema
- From $229/mo (compounded)
- Coverage
- Coverage not published
No. 33 · Grade B−
81/100Found
The widest medication bench in the ranking — compounded, brand-name and oral orforglipron — priced off a membership rather than a sticker.
- Sema
- $289/mo cash month-to-month · $169/mo on a 12-month prepay paid up front ($2,028); the advertised $99 is the in-network INSURANCE rate and still sits before a ~$30 per-visit copay
- Coverage
- All 50 states
No. 35 · Grade B
83/100Semaglutide Online
Semaglutide Online is a LegitScript-certified telehealth platform prescribing compounded and brand-name GLP-1/GIP medications nationwide (excluding Alabama).
- Sema
- From $199/mo (all doses, compounded)
- Coverage
- All 50 states
Rankings reflect the Dose Brief Score — our editorial judgment per the methodology. Pricing and coverage reflect public disclosures at last review and change often — confirm on each provider's site. Not medical advice; see our disclosure.