ShedRx vs RxSpan MD
Two GLP-1 desks, one scoreboard. We put ShedRx and RxSpan MD head-to-head on the published Brief Score — the same six factors, scored the same way.
ShedRx
The verdict
ShedRx takes this head-to-head.
ShedRx scores 87 to 72 on our six-factor Brief Score — A weight-focused program with a low tracked tirzepatide rate and an oral/sublingual route for the needle-averse.
That doesn't make RxSpan MD a bad call — it's best for readers who want to check who is prescribing and who is compounding before they buy, and who will change the pre-selected plan back to monthly unless they actually mean to pay a year up front. Weigh the six factors below against your own priorities before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Brief Score.
Factor by factor
Both desks scored on the six published Brief Score factors. The higher score in each row is marked. See the methodology.
Price, coverage & the tracker
| ShedRx | RxSpan MD | |
|---|---|---|
| Brief Score | 87/100 (B+) | 72/100 (C) |
| Semaglutide | $199/mo on the 1-month plan · $179/mo on 6 months · $159/mo only on a 12-month commitment (all plans carry a 2-month minimum) | $249/mo month-to-month, compounded — the funnel pre-selects a 3-month prepay at $657 up front, and its cheapest rung is $2,327 for a year in one charge |
| Tirzepatide | $299/mo on the 1-month plan · $269/mo on 6 months · $239/mo only on a 12-month commitment (all plans carry a 2-month minimum) | $329/mo month-to-month, compounded — 3 months bills $927 up front, 12 months $3,228 |
| Coverage | Not disclosed | All 50 states claimed — asynchronous review is not available in all of them |
| Brand-name access | Compounded only | Yes |
| Oral / sublingual | Yes | Yes |
| On the tracker | Fallingprice falling | Newnew to the tracker, no prior reading |
ShedRx: Its $239 tirzepatide is the lowest rate among our partners, but only on the 12-month commitment — the 1-month rung is $299.
RxSpan MD: First reading of the live catalog, 8 August 2026, replacing a dataset line that had never been checked against it. Month-to-month is $249 semaglutide and $329 tirzepatide; the ladder runs down to $194 and $269 a month, but only by paying $2,327 or $3,228 in a single charge. The cheapest GLP-1 figures RxSpan publishes anywhere — $179 and $199, in its own product API — are on no storefront page and buy nothing.
● Not sold on either?
CoreAge Rx tops the whole ranking at 94/100.
One price on both molecules that does not climb as you titrate — but the headline $99 and $149 are annual-plan rates, paid in full up front.
Pricing, states and access reflect each provider's public disclosures at last review; the Brief Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.