ShedRx vs Direct Meds
Two GLP-1 providers, one scoreboard. We put ShedRx and Direct Meds head-to-head on the published Brief Score — the same six factors, scored the same way.
Direct Meds
FDA warning letter, September 2025 — issued to directmeds.com, Inc. dba DirectMeds. See the FDA's warning letter database.
The verdict
ShedRx takes this head-to-head.
ShedRx scores 87 to 82 on our six-factor Brief Score — Shed offers injection, oral and branded pathways, but its compounded injection prices have a two-month minimum and lower rates require longer terms.
That doesn't make Direct Meds a bad call — it's best for readers who want a needle-free oral or sublingual route on either molecule and an all-inclusive price with no separate membership — and who are comfortable that the figures are company-stated rather than checkout-verified. Weigh the six factors below against your own priorities before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Brief Score.
Factor by factor
Both providers scored on the six published Brief Score factors. The higher score in each row is marked. See the methodology.
Price, coverage & the tracker
| Compare | ShedRx | Direct Meds |
|---|---|---|
| Brief Score | 87/100 (B+) | 82/100 (B−) |
| Semaglutide | $199/mo 1-month plan; 2-month minimum. Lower rates require 6- or 12-month commitments. Full price details$199/mo on the 1-month plan · $179/mo on 6 months · $159/mo only on a 12-month commitment (all plans carry a 2-month minimum); compounded injection | $249/mo sublingual · $297/mo injectable — both billed monthly on a 3-month minimum commitment |
| Tirzepatide | $299/mo 1-month plan; 2-month minimum. Lower rates require 6- or 12-month commitments. Full price details$299/mo on the 1-month plan · $269/mo on 6 months · $239/mo only on a 12-month commitment (all plans carry a 2-month minimum); compounded injection | $299/mo sublingual · $399/mo injectable — both billed monthly on a 3-month minimum commitment |
| Coverage | Not disclosed | Not publicly listed |
| Brand-name access | Yes | Not confirmed |
| Oral / sublingual | Yes | Yes |
| On the tracker | Fallingprice falling | Stableprice stable |
ShedRx: Its lowest tirzepatide rate is $239, and that needs the 12-month commitment; the one-month rung is $299.
Direct Meds: Prices are provider-listed figures, not checkout-confirmed totals. Confirm the prescribed product, billing term and required fees before paying.
● Not sold on either?
CoreAge Rx tops the whole ranking at 94/100.
CoreAge publishes different starting offers across its pages; the advertised annual rates require a full year paid upfront.
Pricing, states and access reflect each provider's public disclosures at last review; the Brief Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.