Sesame Care vs Direct Meds
Two GLP-1 providers, one scoreboard. We put Sesame Care and Direct Meds head-to-head on the published Brief Score — the same six factors, scored the same way.
Sesame Care
Direct Meds
FDA warning letter, September 2025 — issued to directmeds.com, Inc. dba DirectMeds. See the FDA's warning letter database.
The verdict
Sesame Care takes this head-to-head.
Sesame Care scores 87 to 82 on our six-factor Brief Score — An established national telehealth marketplace with the widest real brand-name GLP-1 access in the ranking — Wegovy (pen and pill), Zepbound, Ozempic and Mounjaro — plus provider-by-provider price transparency.
That doesn't make Direct Meds a bad call — it's best for readers who want a needle-free oral or sublingual route on either molecule and an all-inclusive price with no separate membership — and who are comfortable that the figures are company-stated rather than checkout-verified. Weigh the six factors below against your own priorities before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Brief Score.
Factor by factor
Both providers scored on the six published Brief Score factors. The higher score in each row is marked. See the methodology.
Price, coverage & the tracker
| Sesame Care | Direct Meds | |
|---|---|---|
| Brief Score | 87/100 (B+) | 82/100 (B−) |
| Semaglutide | Brand Wegovy pill from $149/mo at 1.5 and 4 mg only, $299/mo at 9 and 25 mg — plus Sesame care: $59/mo only on the 12-month prepay ($708 in one charge), $69/mo on 6 months, $79/mo on 3 months, otherwise $99 billed every 28 days (13 charges a year) | $249/mo sublingual · $297/mo injectable — both billed monthly on a 3-month minimum commitment |
| Tirzepatide | Brand Zepbound KwikPen $299/mo (2.5 mg), $398 (5 mg), $499 (7.5 mg), $698 (10–15 mg); vial advertised from $299, full dose ladder unconfirmed — plus Sesame care: $59/mo on annual prepay ($708 upfront), otherwise $99 every 28 days | $299/mo sublingual · $399/mo injectable — both billed monthly on a 3-month minimum commitment |
| Coverage | Nationwide marketplace | Not publicly listed |
| Brand-name access | Yes | Compounded only |
| Oral / sublingual | Yes | Yes |
| On the tracker | Stableprice stable | Stableprice stable |
Sesame Care: Prices vary by clinician and treatment; the brand-name Wegovy pill has an advertised entry price around $149. Confirm medication and care charges separately.
Direct Meds: Prices are provider-listed figures, not checkout-confirmed totals. Confirm the prescribed product, billing term and required fees before paying.
● Not sold on either?
CoreAge Rx tops the whole ranking at 94/100.
CoreAge publishes different starting offers across its pages; the advertised annual rates require a full year paid upfront.
Pricing, states and access reflect each provider's public disclosures at last review; the Brief Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.