HealthRX vs Direct Meds
Two GLP-1 providers, one scoreboard. We put HealthRX and Direct Meds head-to-head on the published Brief Score — the same six factors, scored the same way.
HealthRX
Direct Meds
FDA warning letter, September 2025 — issued to directmeds.com, Inc. dba DirectMeds. See the FDA's warning letter database.
The verdict
HealthRX takes this head-to-head.
HealthRX scores 86 to 82 on our six-factor Brief Score — Compounded injectable GLP-1 care with visible plan tables, but conflicting prices and supply-versus-billing periods that need checking before payment.
That doesn't make Direct Meds a bad call — it's best for readers who want a needle-free oral or sublingual route on either molecule and an all-inclusive price with no separate membership — and who are comfortable that the figures are company-stated rather than checkout-verified. Weigh the six factors below against your own priorities before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Brief Score.
Factor by factor
Both providers scored on the six published Brief Score factors. The higher score in each row is marked. See the methodology.
Price, coverage & the tracker
| HealthRX | Direct Meds | |
|---|---|---|
| Brief Score | 86/100 (B) | 82/100 (B−) |
| Semaglutide | $149 first month, then $165/month on Subscribe & Save; product table also shows $1,163 prepaid for 48 weeks, renewing every 12 months | $249/mo sublingual · $297/mo injectable — both billed monthly on a 3-month minimum commitment |
| Tirzepatide | $193 first month, then $214/month on Subscribe & Save; product table also shows $2,123 prepaid for 48 weeks, renewing every 12 months | $299/mo sublingual · $399/mo injectable — both billed monthly on a 3-month minimum commitment |
| Coverage | All 50 states | Not publicly listed |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Injection only | Yes |
| On the tracker | Newnew to the tracker, no prior reading | Stableprice stable |
HealthRX: Subscribe & Save starts at $149 for semaglutide, then $165 per month; tirzepatide starts at $193, then $214. The product tables and separate pricing page disagree on longer plans, so confirm the total before paying.
Direct Meds: Prices are provider-listed figures, not checkout-confirmed totals. Confirm the prescribed product, billing term and required fees before paying.
● Not sold on either?
CoreAge Rx tops the whole ranking at 94/100.
CoreAge publishes different starting offers across its pages; the advertised annual rates require a full year paid upfront.
Pricing, states and access reflect each provider's public disclosures at last review; the Brief Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.