Semaglutide & tirzepatide dosing chart: mg, concentration, and volume, from the FDA labels

Every brand-name GLP-1 pen delivers a specific milligram dose, but the concentration behind that number — how many mg are packed into how much liquid — differs by drug, by dose step, and even by pen type for the same drug. That's a common source of confusion, so here's what each FDA label actually specifies, in one place.

Ozempic (semaglutide, diabetes label)

Ozempic's labeled dosing schedule steps through 0.25 mg, 0.5 mg, 1 mg, and 2 mg once weekly, each held for at least four weeks before increasing¹. The 0.25 mg and 0.5 mg doses come from a pen delivering 2 mg total across 3 mL (a concentration of 0.68 mg/mL); the 1 mg maintenance dose comes from a separate 4 mg/3 mL pen (1.34 mg/mL); and the 2 mg dose comes from an 8 mg/3 mL pen (2.68 mg/mL). Ozempic also ships in single-dose prefilled syringes for the 0.25 mg, 0.5 mg, and 1 mg doses, each delivered in 0.5 mL. The concentration changes between pens specifically so that each pen still delivers the labeled dose in a reasonable click count — it isn't a sign of a stronger or weaker drug at that step, just a different ratio of drug to liquid.

Wegovy (semaglutide, weight-management label)

Wegovy's injection schedule runs 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and 2.4 mg once weekly, stepping up roughly every four weeks toward the 2.4 mg maintenance dose². A higher-dose option, Wegovy HD at 7.2 mg, is available for patients whose prescriber determines additional dose escalation is appropriate. Each dose ships as its own single-dose pen or single-dose syringe at a matched concentration — for example, the 2.4 mg dose is 2.4 mg/0.75 mL — except for the multi-dose Wegovy FlexTouch pen, which delivers four 2.4 mg doses from a 9.6 mg/3 mL (3.2 mg/mL) reservoir. Wegovy is also now available as an oral tablet, dosed once daily starting at 1.5 mg and titrating up to a 25 mg maintenance dose — a completely different delivery method with its own separate schedule, not interchangeable with the injection doses.

Mounjaro (tirzepatide, diabetes label)

Mounjaro's schedule steps through 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg once weekly³. Every dose strength ships at the same underlying volume convention — each single dose is delivered in 0.5 mL from a prefilled pen or vial — but the concentration climbs with the dose, from 5 mg/mL at the 2.5 mg strength up through 30 mg/mL at the 15 mg strength. Mounjaro also ships in a multi-dose vial and a single-patient-use KwikPen, each holding four doses at a given strength; a 15 mg KwikPen, for instance, delivers four 15 mg doses from a 60 mg/2.4 mL (25 mg/mL) reservoir.

Zepbound (tirzepatide, weight-management label)

Zepbound uses the identical dose ladder and concentrations as Mounjaro — 2.5 mg through 15 mg once weekly, at the same mg-per-mL strengths — since both are tirzepatide; only the approved indication and branding differ⁴. That's worth knowing if you're comparing pricing or supply between the two, since a 10 mg Zepbound pen and a 10 mg Mounjaro pen are pharmacologically identical products.

Why this differs from your prescriber's exact plan

This chart reflects each label's standard schedule, not necessarily your individual titration pace — prescribers can extend a step, hold at a lower dose, or otherwise individualize based on tolerability, which is a normal and appropriate deviation from the textbook schedule. For the reasoning behind why the schedule is staged the way it is, and what each step typically feels like, see semaglutide dosing and titration and tirzepatide dosing and titration. And for the mechanics of actually giving the injection — sites, needle length, storage — see how to inject semaglutide and tirzepatide. If you've seen compounded pharmacies advertise doses that don't match any of the strengths above, that's often because compounded products are dispensed from vials at pharmacy-specific concentrations rather than these fixed pen strengths — worth reading alongside GLP-1 microdosing, explained before assuming a nonstandard number is equivalent to a labeled dose.

The honest bottom line

These are the actual FDA-labeled strengths, concentrations, and volumes for the four major brand-name GLP-1 products, pulled directly from each drug's prescribing information — not estimates or a third-party approximation. This is reference information, not a substitute for your prescriber's specific instructions or the printed label that ships with your medication.