RxSpan MD vs Synergy Rx
Two GLP-1 desks, one scoreboard. We put RxSpan MD and Synergy Rx head-to-head on the published Brief Score — the same six factors, scored the same way.
RxSpan MD
The verdict
RxSpan MD takes this head-to-head.
RxSpan MD scores 72 to 67 on our six-factor Brief Score — One of the few desks in this ranking that names its pharmacies, its prescribers and their NPI numbers, and publishes every rung of both ladders — while its own API carries cheaper GLP-1 prices that no page will sell you.
That doesn't make Synergy Rx a bad call — it's best for readers who want to verify who is actually prescribing and compounding their medication, and who will read past the first-month rate to the $249 or $399 they will pay from month two. Weigh the six factors below against your own priorities before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Brief Score.
Factor by factor
Both desks scored on the six published Brief Score factors. The higher score in each row is marked. See the methodology.
Price, coverage & the tracker
| RxSpan MD | Synergy Rx | |
|---|---|---|
| Brief Score | 72/100 (C) | 67/100 (C) |
| Semaglutide | $249/mo month-to-month, compounded — the funnel pre-selects a 3-month prepay at $657 up front, and its cheapest rung is $2,327 for a year in one charge | $249/mo ongoing, compounded ($199 first month only) + an $80 visit fee charged whether or not you get medication |
| Tirzepatide | $329/mo month-to-month, compounded — 3 months bills $927 up front, 12 months $3,228 | $399/mo ongoing, compounded ($349 first month only); the ODT bundles price HIGHER, at $399.67–$399.92/mo |
| Coverage | All 50 states claimed — asynchronous review is not available in all of them | Coverage not published |
| Brand-name access | Yes | Yes |
| Oral / sublingual | Yes | Yes |
| On the tracker | Newnew to the tracker, no prior reading | Newnew to the tracker, no prior reading |
RxSpan MD: First reading of the live catalog, 8 August 2026, replacing a dataset line that had never been checked against it. Month-to-month is $249 semaglutide and $329 tirzepatide; the ladder runs down to $194 and $269 a month, but only by paying $2,327 or $3,228 in a single charge. The cheapest GLP-1 figures RxSpan publishes anywhere — $179 and $199, in its own product API — are on no storefront page and buy nothing.
Synergy Rx: First reading, 7 August 2026. Ongoing month-to-month is $249 semaglutide and $399 tirzepatide; the $199 and $349 figures carried in older datasets are first-month-only rates. An $80 telehealth visit fee sits outside every headline and is charged whether or not medication is dispensed.
● Not sold on either?
CoreAge Rx tops the whole ranking at 94/100.
The steadiest desk in the ranking: one flat, no-step-up price on both molecules, nationwide, and it hasn't moved.
Pricing, states and access reflect each provider's public disclosures at last review; the Brief Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.