Brief Score
94/100
Updated August 2026
CoreAge Rx
The steadiest desk in the ranking: one flat, no-step-up price on both molecules, nationwide, and it hasn't moved.
- Sema
- $99/mo
- Tirz
- $149/mo
- Coverage
- All 50 states
Alternatives to Effecty
Effecty sits at No. 19 in our ranking with a Brief Score of 86. Here are the GLP-1 desks we'd weigh against it — ranked on the same six-factor Brief Score, top down.
Prefer a straight head-to-head? CoreAge Rx vs Effecty.
Our top alternative
More desks worth weighing
No. 16 · Grade B+
87/100Vytora Health
A rare accredited desk that pairs brand-name access with fair mid-market compounded pricing across all 50 states.
- Sema
- $150/mo
- Coverage
- All 50 states
No. 112 · Grade C
72/100TrueMe
TrueMe is a cash-pay telehealth brand offering compounded semaglutide and tirzepatide with added B vitamins, alongside NAD+, sermorelin and glutathione.
- Sema
- From $159/mo (compounded)
- Coverage
- 6 states
No. 23 · Grade B
85/100AgelessRx
A longevity-leaning brand with one of the lowest tracked semaglutide stickers — but a thin disclosure on the rest.
- Sema
- $139/mo
- Coverage
- Not disclosed
No. 98 · Grade C
73/100GobyMeds
Affordable telehealth provider offering compounded semaglutide only.
- Sema
- From $169/mo (all doses, compounded)
- Coverage
- Coverage not published
No. 106 · Grade C
72/100FitRx
FitRx offers brand-name GLP-1s (Ozempic, Wegovy, Zepbound, Mounjaro) with insurance coordination as low as $25/month, plus compounded semaglutide from $151/month without insurance.
- Sema
- From $151/mo (quarterly plan, compounded)
- Coverage
- All 50 states
FDA warning letter, February 2026 — issued to FitRX, LLC dba FitRx. See the FDA's warning letter database.
No. 177 · Grade C
68/100Tuyo Health
Tuyo Health (tuyohealth.com) is a US telehealth weight-loss program founded by Dr.
- Sema
- $155/mo
- Coverage
- Coverage not published
FDA warning letter, September 2025 — issued to Tuyo Health, Inc. dba Tuyo Health. See the FDA's warning letter database.
No. 133 · Grade C
71/100PlushCare
Established virtual primary-care telehealth platform (subsidiary of Transcarent, Inc., a Delaware corporation, alongside Accolade, 2nd.MD, and 98point6 by Transcarent).
- Sema
- From $149/mo (starting dose, compounded)
- Coverage
- All 50 states
No. 268 · Grade C
64/100Zappy Health
Zappy Health is a telehealth weight-loss platform offering both compounded and brand-name GLP-1: compounded semaglutide from $159/month and tirzepatide from $299/month, plus brand Wegovy and Zepbound.
- Sema
- From $159/mo (compounded)
- Coverage
- 42 states
FDA warning letter, February 2026 — issued to Kare Solutions, LLC dba Zappy. See the FDA's warning letter database.
Rankings reflect the Dose Brief Score — our editorial judgment per the methodology. Pricing and coverage reflect public disclosures at last review and change often — confirm on each provider's site. Not medical advice; see our disclosure.