Open Water Rx vs Synergy Rx
Two GLP-1 desks, one scoreboard. We put Open Water Rx and Synergy Rx head-to-head on the published Brief Score — the same six factors, scored the same way.
Synergy Rx
The verdict
Synergy Rx takes this head-to-head.
Synergy Rx scores 67 to 56 on our six-factor Brief Score — One of the few desks in this ranking that names both its prescribers and its pharmacies — wrapped around an intro rate that steps up in month two, an $80 visit fee that appears in no headline, and an ODT bundle ladder that costs more per month than not bundling.
That doesn't make Open Water Rx a bad call — it's best for readers who want transparency listing only — verify against vetted providers first. Weigh the six factors below against your own priorities before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Brief Score.
Factor by factor
Both desks scored on the six published Brief Score factors. The higher score in each row is marked. See the methodology.
Price, coverage & the tracker
| Open Water Rx | Synergy Rx | |
|---|---|---|
| Brief Score | 56/100 (C) | 67/100 (C) |
| Semaglutide | From $249/mo (compounded) | $249/mo ongoing, compounded ($199 first month only) + an $80 visit fee charged whether or not you get medication |
| Tirzepatide | From $339/mo (compounded) | $399/mo ongoing, compounded ($349 first month only); the ODT bundles price HIGHER, at $399.67–$399.92/mo |
| Coverage | Coverage not published | Coverage not published |
| Brand-name access | Yes | Yes |
| Oral / sublingual | Yes | Yes |
| On the tracker | Newnew to the tracker, no prior reading | Newnew to the tracker, no prior reading |
Open Water Rx: New to the tracker on 1 August 2026. The published line reads From $249/mo (compounded) at our first reading; there is no earlier reading of ours to compare it against yet.
Synergy Rx: First reading, 7 August 2026. Ongoing month-to-month is $249 semaglutide and $399 tirzepatide; the $199 and $349 figures carried in older datasets are first-month-only rates. An $80 telehealth visit fee sits outside every headline and is charged whether or not medication is dispensed.
● Not sold on either?
CoreAge Rx tops the whole ranking at 94/100.
The steadiest desk in the ranking: one flat, no-step-up price on both molecules, nationwide, and it hasn't moved.
Pricing, states and access reflect each provider's public disclosures at last review; the Brief Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.