Open Water Rx vs RxSpan MD
Two GLP-1 desks, one scoreboard. We put Open Water Rx and RxSpan MD head-to-head on the published Brief Score — the same six factors, scored the same way.
RxSpan MD
The verdict
RxSpan MD takes this head-to-head.
RxSpan MD scores 72 to 56 on our six-factor Brief Score — One of the few desks in this ranking that names its pharmacies, its prescribers and their NPI numbers, and publishes every rung of both ladders — while its own API carries cheaper GLP-1 prices that no page will sell you.
That doesn't make Open Water Rx a bad call — it's best for readers who want transparency listing only — verify against vetted providers first. Weigh the six factors below against your own priorities before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Brief Score.
Factor by factor
Both desks scored on the six published Brief Score factors. The higher score in each row is marked. See the methodology.
Price, coverage & the tracker
| Open Water Rx | RxSpan MD | |
|---|---|---|
| Brief Score | 56/100 (C) | 72/100 (C) |
| Semaglutide | From $249/mo (compounded) | $249/mo month-to-month, compounded — the funnel pre-selects a 3-month prepay at $657 up front, and its cheapest rung is $2,327 for a year in one charge |
| Tirzepatide | From $339/mo (compounded) | $329/mo month-to-month, compounded — 3 months bills $927 up front, 12 months $3,228 |
| Coverage | Coverage not published | All 50 states claimed — asynchronous review is not available in all of them |
| Brand-name access | Yes | Yes |
| Oral / sublingual | Yes | Yes |
| On the tracker | Newnew to the tracker, no prior reading | Newnew to the tracker, no prior reading |
Open Water Rx: New to the tracker on 1 August 2026. The published line reads From $249/mo (compounded) at our first reading; there is no earlier reading of ours to compare it against yet.
RxSpan MD: First reading of the live catalog, 8 August 2026, replacing a dataset line that had never been checked against it. Month-to-month is $249 semaglutide and $329 tirzepatide; the ladder runs down to $194 and $269 a month, but only by paying $2,327 or $3,228 in a single charge. The cheapest GLP-1 figures RxSpan publishes anywhere — $179 and $199, in its own product API — are on no storefront page and buy nothing.
● Not sold on either?
CoreAge Rx tops the whole ranking at 94/100.
The steadiest desk in the ranking: one flat, no-step-up price on both molecules, nationwide, and it hasn't moved.
Pricing, states and access reflect each provider's public disclosures at last review; the Brief Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.