ShedRx vs Onyx Weight Loss
Two GLP-1 desks, one scoreboard. We put ShedRx and Onyx Weight Loss head-to-head on the published Brief Score — the same six factors, scored the same way.
Onyx Weight Loss
The verdict
ShedRx takes this head-to-head.
ShedRx scores 87 to 65 on our six-factor Brief Score — A weight-focused program with a low tracked tirzepatide rate and an oral/sublingual route for the needle-averse.
That doesn't make Onyx Weight Loss a bad call — it's best for readers who want np-led glp-1 telehealth across 8 states; sema from $228/mo or tirz from $280/mo, med+ship incl. Weigh the six factors below against your own priorities before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Brief Score.
Factor by factor
Both desks scored on the six published Brief Score factors. The higher score in each row is marked. See the methodology.
Price, coverage & the tracker
| ShedRx | Onyx Weight Loss | |
|---|---|---|
| Brief Score | 87/100 (B+) | 65/100 (C) |
| Semaglutide | $199/mo | From $99/mo (compounded) |
| Tirzepatide | $299/mo | From $280/mo (starting dose, compounded) |
| Coverage | Not disclosed | 8 states |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Yes | Injection only |
| On the tracker | Fallingprice falling | Newnew to the tracker, no prior reading |
ShedRx: Competitive tirzepatide rate trimmed further this cycle — cheapest tirz among our partner desks.
Onyx Weight Loss: New to the tracker on 1 August 2026. The published line reads From $99/mo (compounded) at our first reading; there is no earlier reading of ours to compare it against yet.
● Not sold on either?
CoreAge Rx tops the whole board at 94/100.
The steadiest desk on the board: one flat, no-step-up price on both molecules, nationwide, and it hasn't moved.
Pricing, states and access reflect each provider's public disclosures at last review; the Brief Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.